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Effect of Whole Fruit on Glycemic Control in Adults With Type 2 Diabetes

October 28, 2019


The University of Alabama at Birmingham is studying how a healthy diet can positively affect persons diagnosed with type 2 diabetes or prevent those with a genetic predisposition to type 2 diabetes from developing it in the future. Since fruit is an inclusion of the healthy Mediterranean diet, researchers of this clinical trial will assess its effectiveness on controlling blood sugar.


Study Information

The study includes a controlled feeding trial, monitored while eating a diet rich in whole fruit for 12 weeks. The results will be assessed to determine if this measure can lead to diabetes remission and improve blood sugar, liver fat, and cardiovascular health in adults with type 2 diabetes. The analysis will include:

  • Diabetes remission rate
  • Medication effect
  • Fasting blood sugar and HbA1c
  • Oral blood sugar tolerance test and continuous monitoring


Inclusion Criteria

  • All sexes, ages 20-65 years old
  • Body Mass Index (BMI) between 27.0-45.0 kg/m^2
  • Diagnosed with type 2 diabetes in the past 6 years
  • HbA1c levels between 6.0-9.5%%


Exclusion Criteria

  • Currently on insulin
  • Diagnosed with diabetes before age 18
  • Estimated glomerular filtration rate levels greater than 45 ml/min per 1.732 m^2
  • Heart attack in the past 6 months
  • Currently on weight loss medication
  • Change in the dosage of a medication that may affect study goals within the past 3 months
  • Clinically significant laboratory abnormality (e.g. abnormal hemoglobin levels)
  • Gastrointestinal disease, major gastrointestinal surgery, or gallstones
  • Cardiovascular, renal, cardiac, liver, lung, adrenal, or nervous system disease that might compromise safety or study data
  • Evidence of cancer (other than non-melanoma skin cancer) within the last 5 years
  • Lost or gained more than 11 lb of weight in the past 6 months
  • Pregnant, planning to become pregnant in the next 12 months
  • Currently breastfeeding
  • Psychiatric condition that would affect the ability to participate in the study
  • Not able to eat the provided study meals
  • Unable to adhere to the diet
  • Unable to do the MRI/MRS abdominal scan



The study is being held at the Department of Nutrition Sciences of the University of Alabama at Birmingham in Birmingham, Alabama, 35233. If you have any questions feel free to contact Courtney Peterson, Ph.D, at 205-934-0122 or at You may also contact Cody Hanick, M.S, at (262) 923-0672 or at



This clinical trial is sponsored by the University of Alabama at Birmingham. The Principal Investigator is Cody Hanick, M.S.

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